Description
Human CNGA1 Recombinant Protein (N-His)
Human CNGA1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Glu446-Thr686, with an N-terminal His tag. Predicted molecular weight: 29.1 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Cyclic nucleotide-gated channel alpha-1 (CNGA1) is a ~79 kDa protein. Pore-forming subunit of the rod cyclic nucleotide-gated channel. For research use only.
Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations.
| Product Name: | Human CNGA1 Recombinant Protein (N-His) |
| SKU: | GXRP07577 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | cGMP-gated cation channel alpha-1, Cyclic nucleotide-gated cation channel 1, Cyclic nucleotide-gated channel alpha-1, CNG channel alpha-1, CNG-1, CNG1, Cyclic nucleotide-gated channel, photoreceptor, Rod photoreceptor cGMP-gated channel subunit alpha, CNGA1, CNCG, CNCG1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Glu446-Thr686 |
| Calculated MW: | 29.1 kDa |
| UniProt: | P29973 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
