Description
Human COPS5 Recombinant Protein (N-His)
Human COPS5 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Lys230, with an N-terminal His tag. Predicted molecular weight: 28.01 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. COP9 signalosome complex subunit 5 is a ~37 kDa protein. Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. For research use only.
The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins.
| Product Name: | Human COPS5 Recombinant Protein (N-His) |
| SKU: | GXRP09473 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; 3.4.-.-; Jun activation domain-binding protein 1; COPS5; CSN5; JAB1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Lys230 |
| Calculated MW: | 28.01 kDa |
| UniProt: | Q92905 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
