Description
Human DAB2IP Recombinant Protein (N-His)
Human DAB2IP Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Glu154-Thr655, with an N-terminal His tag. Predicted molecular weight: 59.59 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Disabled homolog 2-interacting protein is a ~131 kDa protein. Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. For research use only.
Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli.
| Product Name: | Human DAB2IP Recombinant Protein (N-His) |
| SKU: | GXRP12305 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | AF9Q34, AIP-1, AIP1, ASK-interacting protein 1, DAB2 interaction protein, DAB2-interacting protein, DAB2IP, DOC-2/DAB-2 interactive protein, Disabled homolog 2-interacting protein, KIAA1743 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Glu154-Thr655 |
| Calculated MW: | 59.59 kDa |
| UniProt: | Q5VWQ8 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
