Description
Human DHX16 Recombinant Protein (N-His)
Human DHX16 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Glu364-Glu746, with an N-terminal His tag. Predicted molecular weight: 44.96 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 is a ~119 kDa protein. Required for pre-mRNA splicing as a component of the spliceosome. For research use only.
Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses.
| Product Name: | Human DHX16 Recombinant Protein (N-His) |
| SKU: | GXRP07375 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16, 3.6.4.13, ATP-dependent RNA helicase #3, DEAH-box protein 16, DHX16, DBP2, DDX16, KIAA0577, PRP2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Glu364-Glu746 |
| Calculated MW: | 44.96 kDa |
| UniProt: | O60231 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
