Description
Human DTX3L Recombinant Protein (N-His)
Human DTX3L Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser233-Gly510, with an N-terminal His tag. Predicted molecular weight: 34.16 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. E3 ubiquitin-protein ligase DTX3L is a ~83 kDa protein. E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses. For research use only.
Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4. In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
| Product Name: | Human DTX3L Recombinant Protein (N-His) |
| SKU: | GXRP11664 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | B-lymphoma- and BAL-associated protein, BBAP, DTX3L, E3 ubiquitin-protein ligase DTX3L, EC:2.3.2.27, Protein deltex-3-like, RING-type E3 ubiquitin transferase DTX3L, Rhysin-2, Rhysin2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser233-Gly510 |
| Calculated MW: | 34.16 kDa |
| UniProt: | Q8TDB6 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
