Description
Human DVL1 Recombinant Protein (N-His)
Human DVL1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Arg150-Lys285, with an N-terminal His tag. Predicted molecular weight: 17.43 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Segment polarity protein dishevelled homolog DVL-1 (DVL1) is a ~75 kDa protein. Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. For research use only.
Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
| Product Name: | Human DVL1 Recombinant Protein (N-His) |
| SKU: | GXRP00073 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | DVL1, DSH homolog 1, Dishevelled-1, Segment polarity protein dishevelled homolog DVL-1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Arg150-Lys285 |
| Calculated MW: | 17.43 kDa |
| UniProt: | O14640 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
