Description
Human DZIP1 Recombinant Protein (N-His)
Human DZIP1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Asp114, with an N-terminal His tag. Predicted molecular weight: 14.35 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Cilium assembly protein DZIP1 is a ~98 kDa protein. Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body. For research use only.
At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium. Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium. It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN. Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm.
| Product Name: | Human DZIP1 Recombinant Protein (N-His) |
| SKU: | GXRP11938 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Cilium assembly protein DZIP1, DAZ-interacting protein 1/2, DAZ-interacting zinc finger protein 1, DZIP, DZIP1, DZIP2, KIAA0996 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Asp114 |
| Calculated MW: | 14.35 kDa |
| UniProt: | Q86YF9 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
