Human FKBP1B Recombinant Protein (RPPB1641)
- SKU:
- RPPB1641
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P68106
- Research Area:
- Enzymes
Description
| Product Name: | Human FKBP1B Recombinant Protein |
| Product Code: | RPPB1641 |
| Size: | 20µg |
| Species: | Human |
| Target: | FKBP1B |
| Synonyms: | Peptidyl-prolyl cis-trans isomerase FKBP1B, PPIase FKBP1B, 12.6 kDa FK506-binding protein, 12.6 kDa FKBP, FKBP-12.6, FK506-binding protein 1B, FKBP-1B, Immunophilin FKBP12.6, Rotamase, h-FKBP-12, FKBP1B, FKBP12.6, FKBP1L, FKBP9, OTK4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The FKBP1B solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE analysis. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH RSMGVEIETI SPGDGRTFPK KGQTCVVHYT GMLQNGKKFD SSRDRNKPFK FRIGKQEVIK GFEEGAAQMS LGQRAKLTCT PDVAYGATGH PGVIPPNATL IFDVELLNLE |
| Biological Activity: | Specific activity is > 300 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin. |
Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) belongs to the immunophilin protein family which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1B is a cis-trans prolyl isomerase which binds the immunosuppressants FK506 and rapamycin. FKBP1B is extremely similar to the FK506-binding protein 1A. The physiological role of FKBP1B is thought to be in excitation-contraction coupling in cardiac muscle.
FKBP1B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 130 amino acids (1-108) and having a molecular mass of 14.2kDa.FKBP1B is fused to a 22 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FKBP1B: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Isomerase; EC 5.2.1.8 Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: cytoplasm; cytosol; membrane; sarcoplasmic reticulum membrane; Z disc Molecular Function:calcium channel inhibitor activity; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; receptor binding; ryanodine-sensitive calcium-release channel activity Biological Process: 'de novo' protein folding; cytosolic calcium ion homeostasis; negative regulation of heart rate; negative regulation of protein phosphatase type 2B activity; negative regulation of release of sequestered calcium ion into cytosol; positive regulation of sequestering of calcium ion; protein maturation via protein folding; protein peptidyl-prolyl isomerization; protein refolding; response to redox state |
| NCBI Summary: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P68106 |
| NCBI GenInfo Identifier: | 61224185 |
| NCBI Gene ID: | 2281 |
| NCBI Accession: | P68106.2 |
| UniProt Secondary Accession: | P68106,Q13664, Q16645, Q53TM2, Q9BQ40, |
| UniProt Related Accession: | P68106 |
| Molecular Weight: | 8,802 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase FKBP1B |
| NCBI Synonym Full Names: | FK506 binding protein 1B |
| NCBI Official Symbol: | FKBP1B�� |
| NCBI Official Synonym Symbols: | OTK4; FKBP1L; PKBP1L; PPIase; FKBP12.6�� |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase FKBP1B |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase FKBP1B |
| UniProt Synonym Protein Names: | 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FKBP-12.6; FK506-binding protein 1B; FKBP-1B; Immunophilin FKBP12.6; Rotamase; h-FKBP-12 |
| Protein Family: | Peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | FKBP1B�� |
| UniProt Entry Name: | FKB1B_HUMAN |
