Description
Human FOXK2 Recombinant Protein (N-His)
Human FOXK2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ala36-Ser159&Ser262-Arg348, with an N-terminal His tag. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Forkhead box protein K2 is a ~69 kDa protein. Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy. For research use only.
Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4. Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate.
| Product Name: | Human FOXK2 Recombinant Protein (N-His) |
| SKU: | GXRP13707 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | FOXK2, Forkhead box protein K2, G/T-mismatch specific binding protein, ILF, ILF1, Interleukin enhancer-binding factor 1, nGTBP |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ala36-Ser159&Ser262-Arg348 |
| UniProt: | Q01167 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
