Human GGPS1 Recombinant Protein (RPPB1689)
- SKU:
- RPPB1689
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95749
- Research Area:
- Enzymes
Description
| Product Name: | Human GGPS1 Recombinant Protein |
| Product Code: | RPPB1689 |
| Size: | 20µg |
| Species: | Human |
| Target: | GGPS1 |
| Synonyms: | GGPPS, GGPPS1, GGPP synthetase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | GGPS1 Human recombinant (1mg/ml) protein solution contains 20mM Tris-HCl pH-8, 1mM DTT & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLNTL GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN IDIKKYCVHY LEDVGSFEYT RNTLKELEAK AYKQIDARGG NPELVALVKH LSKMFKEENE |
GGPS1 is PART of the prenyltransferase family. GGPS1 is widely expressed in testis, heart and skeletal muscle, GGPS1 is localized in the cytoplasm and catalyzes the formation of geranylgeranyl pyrophosphate, a precursor of geranylgeranylated proteins and carotenoids. GGPS1 is a significant enzyme that is responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor.
GGPS1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 320 amino acids (1-300 a.a.) and having a molecular mass of 37 kDa. The GGPS1 is fused to a 20 amino acids His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GGPS1: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Belongs to the FPP/GGPP synthase family. |
| UniProt Protein Details: | Protein type:Transferase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.10; EC 2.5.1.29; Motility/polarity/chemotaxis; EC 2.5.1.1 Chromosomal Location of Human Ortholog: 1q43 Cellular Component: cytosol Molecular Function:geranyltranstransferase activity; dimethylallyltranstransferase activity; farnesyltranstransferase activity; metal ion binding Biological Process: isoprenoid metabolic process; geranylgeranyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; farnesyl diphosphate biosynthetic process; cholesterol biosynthetic process |
| NCBI Summary: | This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010] |
| UniProt Code: | O95749 |
| NCBI GenInfo Identifier: | 6831549 |
| NCBI Gene ID: | 9453 |
| NCBI Accession: | O95749.1 |
| UniProt Related Accession: | O95749 |
| Molecular Weight: | 28kDa; 34kDa |
| NCBI Full Name: | Geranylgeranyl pyrophosphate synthase |
| NCBI Synonym Full Names: | geranylgeranyl diphosphate synthase 1 |
| NCBI Official Symbol: | GGPS1�� |
| NCBI Official Synonym Symbols: | GGPPS; GGPPS1�� |
| NCBI Protein Information: | geranylgeranyl pyrophosphate synthase |
| UniProt Protein Name: | Geranylgeranyl pyrophosphate synthase |
| UniProt Synonym Protein Names: | (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase (EC:2.5.1.1); Farnesyl diphosphate synthase; Farnesyltranstransferase (EC:2.5.1.29); Geranylgeranyl diphosphate synthase; Geranyltranstransferase (EC:2.5.1.10) |
| UniProt Gene Name: | GGPS1�� |
| UniProt Entry Name: | GGPPS_HUMAN |
