Description
Human GRM2 Recombinant Protein (N-His)
Human GRM2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Glu19-Trp567, with an N-terminal His tag. Predicted molecular weight: 63.33 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Metabotropic glutamate receptor 2 is a ~95 kDa protein. Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate. For research use only.
Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling. Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
| Product Name: | Human GRM2 Recombinant Protein (N-His) |
| SKU: | GXRP10887 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | GPRC1B, GRM2, MGLUR2, Metabotropic glutamate receptor 2, mGluR2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Glu19-Trp567 |
| Calculated MW: | 63.33 kDa |
| UniProt: | Q14416 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
