Human GSTM1 Recombinant Protein (RPPB1761)
- SKU:
- RPPB1761
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P09488
- Research Area:
- Enzymes
Description
| Product Name: | Human GSTM1 Recombinant Protein |
| Product Code: | RPPB1761 |
| Size: | 10µg |
| Species: | Human |
| Target: | GSTM1 |
| Synonyms: | GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU,MU-1, GST HB subunit 4, GST class-mu 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | GSTM1 protein solution (0.25mg/ml) contains 20mM Tris-HClbuffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH RSMPMILGYW DIRGLAHAIR LLLEYTDSSY EEKKYTMGDA PDYDRSQWLNEKFKLGLDFP NLPYLIDGAH KITQSNAILC YIARKHNLCG ETEEEKIRVD ILENQTMDNH MQLGMICYNPEFEKLKPKYL EELPEKLKLY SEFLGKRPWF AGNKGLEKIS AYMKSSRFLP RPVFSKMAVW GNK |
Cytosolic and membrane-bound types of GST are encoded by 2 different supergene families. There are 8 classes of the soluble cytoplasmic mammalian GST: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are arranged in a gene cluster on chromosome 1p13.3 and aare highly polymorphic. These genetic differences can change an individual's resistance to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with the rise in a number of cancers.
GSTM1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 203 amino acids (1-181 a.a) andhaving a molecular mass of 23.6kDa.GSTM1 is fused to a 22 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| NCBI Summary: | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09488 |
| NCBI GenInfo Identifier: | 121735 |
| NCBI Gene ID: | 2944 |
| NCBI Accession: | P09488.3 |
| UniProt Related Accession: | P09488 |
| Molecular Weight: | |
| NCBI Full Name: | Glutathione S-transferase Mu 1 |
| NCBI Synonym Full Names: | glutathione S-transferase mu 1 |
| NCBI Official Symbol: | GSTM1�� |
| NCBI Official Synonym Symbols: | MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; GSTM1a-1a; GSTM1b-1b�� |
| NCBI Protein Information: | glutathione S-transferase Mu 1 |
| UniProt Protein Name: | Glutathione S-transferase Mu 1 |
| UniProt Synonym Protein Names: | GST HB subunit 4; GST class-mu 1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4 |
| Protein Family: | Glutathione S-transferase |
| UniProt Gene Name: | GSTM1�� |
| UniProt Entry Name: | GSTM1_HUMAN |
