Description
Human HSD17B12 Recombinant Protein (N-His)
Human HSD17B12 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Asn312, with an N-terminal His tag. Predicted molecular weight: 36.49 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) is a ~34 kDa protein. Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. For research use only.
This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
| Product Name: | Human HSD17B12 Recombinant Protein (N-His) |
| SKU: | GXRP02411 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | 3-ketoacyl-CoA reductase, SDR12C1, Estradiol 17-beta-dehydrogenase 12, Very-long-chain 3-oxoacyl-CoA reductase, KAR, 17-beta-HSD 12, HSD17B12, 17-beta-hydroxysteroid dehydrogenase 12, Short chain dehydrogenase/reductase family 12C member 1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Asn312 |
| Calculated MW: | 36.49 kDa |
| UniProt: | Q53GQ0 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
