Human HSD17B14 Recombinant Protein (RPPB1834)
- SKU:
- RPPB1834
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BPX1
- Research Area:
- Enzymes
Description
| Product Name: | Human HSD17B14 Recombinant Protein |
| Product Code: | RPPB1834 |
| Size: | 20µg |
| Species: | Human |
| Target: | HSD17B14 |
| Synonyms: | 17-beta-hydroxysteroid dehydrogenase 14, 17-beta-HSD 14, 17-beta-hydroxysteroid dehydrogenase DHRS10, Dehydrogenase/reductase SDR family member 10, Retinal short-chain dehydrogenase/reductase retSDR3, HSD17B14, DHRS10, SDR3, SDR47C1, retSDR3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The HSD17B14 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMATG TRYAGKVVVV TGGGRGIGAG IVRAFVNSGA RVVICDKDES GGRALEQELP GAVFILCDVT QEDDVKTLVS ETIRRFGRLD CVVNNAGHHP PPQRPEETSA QGFRQLLELN LLGTYTLTKL ALPYLRKSQG NVINISSLVG AIGQAQAVPY VATKGAVTAM TKALALDESP YGVRVNCISP GNIWTPLWEE LAALMPDPRA TIREGMLAQP LGRMGQPAEV GAAAVFLASE ANFCTGIELL VTGGAELGYG CKASRSTPVD APDIPS |
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) is a member of the 17-beta-HSD family of proteins, which regulate the availability of steroids within various tissues throughout the body. 17-beta-hydroxysteroid dehydrogenases (HSD17B14) are mainly involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics. HSD17B14 exists as a homotetramer that localizes to the cytoplasm and is highly expressed in the brain, placenta, liver and kidney.
HSD17B14 Human Recombinant fused with a 36 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 306 amino acids (1-270 a.a.) and having a molecular mass of 32.4kDa. The HSD17B14 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HSD17B14: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3- beta,17-beta-diol (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family.Protein type: EC 1.1.1.-; OxidoreductaseChromosomal Location of Human Ortholog: 19q13.33Cellular Component: cytosolMolecular Function: estradiol 17-beta-dehydrogenase activity; identical protein binding; protein binding; testosterone 17-beta-dehydrogenase (NADP+) activityBiological Process: estrogen biosynthetic process; steroid catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | 17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | Q9BPX1 |
| NCBI GenInfo Identifier: | 59889578 |
| NCBI Gene ID: | 51171 |
| NCBI Accession: | NP_057330.2 |
| UniProt Secondary Accession: | Q9BPX1,Q9UKU3 |
| UniProt Related Accession: | Q9BPX1 |
| Molecular Weight: | 44.3kD |
| NCBI Full Name: | 17-beta-hydroxysteroid dehydrogenase 14 |
| NCBI Synonym Full Names: | hydroxysteroid 17-beta dehydrogenase 14 |
| NCBI Official Symbol: | HSD17B14�� |
| NCBI Official Synonym Symbols: | DHRS10; SDR47C1; retSDR3�� |
| NCBI Protein Information: | 17-beta-hydroxysteroid dehydrogenase 14 |
| UniProt Protein Name: | 17-beta-hydroxysteroid dehydrogenase 14 |
| UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase DHRS10; Dehydrogenase/reductase SDR family member 10; Retinal short-chain dehydrogenase/reductase retSDR3; Short chain dehydrogenase/reductase family 47C member 1 |
| Protein Family: | 17-beta-hydroxysteroid dehydrogenase |
| UniProt Gene Name: | HSD17B14�� |
| UniProt Entry Name: |
