Description
Human IGFBP3 Recombinant Protein (N-His)
Human IGFBP3 Recombinant Protein (N-His) is a recombinant protein expressed in mammalian cells, spanning Gly28-Lys291, with an N-terminal His tag. Predicted molecular weight: 32.68 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Insulin-like growth factor-binding protein 3 is a ~31 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. For research use only.
Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis. Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1.
| Product Name: | Human IGFBP3 Recombinant Protein (N-His) |
| SKU: | GXRP10667 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | IBP-3, IBP3, IGF-binding protein 3, IGFBP-3, IGFBP3, Insulin-like growth factor-binding protein 3 |
| Tag: | N-His |
| Expression Host: | Mammalian cells |
| Protein Length: | Gly28-Lys291 |
| Calculated MW: | 32.68 kDa |
| UniProt: | P17936 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
