Human IL12B/IL-12 p40/NKSF2 (DF 6002) Antibody is a research-grade biosimilar monoclonal antibody. It is a human IgG antibody. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: functional assays. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Interleukin-12 subunit beta (IL12B/IL-12 p40) is a ~37 kDa protein. Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. _x000D_
Product Name:
Human IL12B/IL-12 p40/NKSF2 (DF 6002) Antibody
SKU:
GXBS02010
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Applications:
Functional assay
Expression Host:
Mammalian cells
Synonyms:
DF-6002, DF6002, DF6002
Biological Activity:
DF6002 (200 nM) specifically binds to IL-12 receptor-expressing CD4 + T cells, CD8 + T cells, NK cells, and weakly to B cells in activated human PBMCs [1]. DF6002 (0.00596-6250 pM; 72 h) induces IFN-γ production in activated human PBMCs with an EC 50 of 2.99 pM [1]. DF6002 (200 nM) specifically binds to IL-12 receptor-expressing CD4 + T cells, CD8 + T cells, NK cells, and weakly to B cells in activated cynomolgus monkey PBMCs [1]. DF6002 (0.00596-6250 pM; 72 h) induces IFN-γ production in activated cynomolgus monkey PBMCs with an EC 50 of 6.91 pM [1]. Parmacokinetics Species Dose Route T 1/2 Cynomolgus Monkey [1] 1 mg/kg i.v. 17.4-30.5 h DF6002 (1-19 ug/kg; i.v.) exhibits prolonged in vivo half-life in cynomolgus monkeys, induces a sustained, potent IFNγ response at 1 ug/kg, and is well tolerated at doses up to 19 ug/kg [1].
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
