Description
Human IL1A/IL1F1 Recombinant Protein (C-His)
Human IL1A/IL1F1 Recombinant Protein (C-His) is a recombinant protein expressed in E. coli, spanning Ser113-Ala271, with a C-terminal His tag. Predicted molecular weight: 19.24 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Interleukin-1 alpha (IL1A/IL1F1) is a ~30 kDa protein. Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. For research use only.
After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage.
| Product Name: | Human IL1A/IL1F1 Recombinant Protein (C-His) |
| SKU: | GXRP00445 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | IL1F1, Interleukin-1 alpha, IL1A, Hematopoietin-1, IL-1 alpha |
| Tag: | C-His |
| Expression Host: | E. coli |
| Protein Length: | Ser113-Ala271 |
| Calculated MW: | 19.24 kDa |
| UniProt: | P01583 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
