Description
Human IL1RL1/ST2 Recombinant Protein (C-His)
Human IL1RL1/ST2 Recombinant Protein (C-His) is a recombinant protein expressed in mammalian cells, spanning Lys19-Phe328, with a C-terminal His tag. Predicted molecular weight: 38.26 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Interleukin-1 receptor-like 1 (IL1RL1/ST2) is a ~63 kDa protein. Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. For research use only.
Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.
| Product Name: | Human IL1RL1/ST2 Recombinant Protein (C-His) |
| SKU: | GXRP02007 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | T1, DER4, Interleukin-1 receptor-like 1, ST2, IL1RL1, Protein ST2 |
| Tag: | C-His |
| Expression Host: | Mammalian cells |
| Protein Length: | Lys19-Phe328 |
| Calculated MW: | 38.26 kDa |
| UniProt: | Q01638 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
