Description
Human IRGQ Recombinant Protein (N-His)
Human IRGQ Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Thr331, with an N-terminal His tag. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Immunity-related GTPase family Q protein is a ~62 kDa protein. Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation. For research use only.
Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation. Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response. In contrast to other members of the family, does not show GTPase activity.
| Product Name: | Human IRGQ Recombinant Protein (N-His) |
| SKU: | GXRP13277 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | IRGQ, IRGQ1, Immunity-related GTPase family Q protein |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Thr331 |
| UniProt: | Q8WZA9 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
