Description
Human JAK3 Recombinant Protein (N-His)
Human JAK3 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Gly46-Thr209, with an N-terminal His tag. Predicted molecular weight: 20.59 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Tyrosine-protein kinase JAK3 is a ~125 kDa protein. Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. For research use only.
Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor.
| Product Name: | Human JAK3 Recombinant Protein (N-His) |
| SKU: | GXRP01768 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | L-JAK, Janus kinase 3, Leukocyte janus kinase, JAK-3, Tyrosine-protein kinase JAK3, JAK3 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Gly46-Thr209 |
| Calculated MW: | 20.59 kDa |
| UniProt: | P52333 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
