Description
Human JMJD1C Recombinant Protein (N-His)
Human JMJD1C Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Glu2141-Glu2502, with an N-terminal His tag. Predicted molecular weight: 43.62 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Jumonji domain-containing protein 1C is a ~284 kDa protein. Demethylates lysine in proteins, such as STAT3 or MDC1. For research use only.
Demethylates MDC1, thereby promoting MDC1-RNF8 interaction and facilitating RNF8-dependent MDC1 ubiquitination essential for double-strand break (DSB) repair. Demethylation of STAT3 at 'Lys-140' facilitates its interactions with the phosphatase PTPN6 and restrains STAT3 activation. It is uncertain whether JMJD1C removes methyl groups from histone proteins as the other JMJD1/KDM3 proteins do. Nevertheless, JMJD1C may act as a context-specific histone demethylase.
| Product Name: | Human JMJD1C Recombinant Protein (N-His) |
| SKU: | GXRP11523 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | EC:1.14.11.-, JHDM2C, JMJD1C, Jumonji domain-containing protein 1C, KIAA1380, Probable JmjC domain-containing histone demethylation protein 2C, TR-interacting protein 8, TRIP-8, TRIP8, Thyroid receptor-interacting protein 8 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Glu2141-Glu2502 |
| Calculated MW: | 43.62 kDa |
| UniProt: | Q15652 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
