Description
Human KIF7 Recombinant Protein (N-His)
Human KIF7 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Thr697-Gln1030, with an N-terminal His tag. Predicted molecular weight: 41.63 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Kinesin-like protein KIF7 is a ~150 kDa protein. Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms. For research use only.
Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes. Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand.
| Product Name: | Human KIF7 Recombinant Protein (N-His) |
| SKU: | GXRP04946 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | KIF7, Kinesin-like protein KIF7 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Thr697-Gln1030 |
| Calculated MW: | 41.63 kDa |
| UniProt: | Q2M1P5 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
