Human KLB/Beta-klotho Antibody (MK-3655) is a research-grade biosimilar monoclonal antibody targeting Klotho beta-like protein. It is a mouse IgG2a-kappa antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Beta-klotho (KLB) is a ~119 kDa protein. Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.
Product Name:
Human KLB/Beta-klotho Antibody (MK-3655)
SKU:
GXBS02173
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Clone:
MK-3655
Target:
Klotho beta-like protein
Isotype:
IgG2a-kappa
Host Species:
Mouse
Reactivity:
Human
Applications:
ELISA, FACS, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
MK-3655, NGM-313, NGM313
Purity:
>95% purity as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
