Description
Human KPTN Recombinant Protein (N-His)
Human KPTN Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Ser396, with an N-terminal His tag. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. KICSTOR complex protein kaptin is a ~48 kDa protein. As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. For research use only.
Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
| Product Name: | Human KPTN Recombinant Protein (N-His) |
| SKU: | GXRP13111 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Actin-associated protein 2E4, KICSTOR complex protein kaptin, KPTN |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Ser396 |
| UniProt: | Q9Y664 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
