Description
Human LARP7 Recombinant Protein (N-His)
Human LARP7 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Asn187, with an N-terminal His tag. Predicted molecular weight: 23.81 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. La-related protein 7 (LARP7) is a ~66 kDa protein. RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. For research use only.
Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex.
| Product Name: | Human LARP7 Recombinant Protein (N-His) |
| SKU: | GXRP04375 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | La ribonucleoprotein domain family member 7, La-related protein 7, hLARP7, P-TEFb-interaction protein for 7SK stability, LARP7, PIP7S |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Asn187 |
| Calculated MW: | 23.81 kDa |
| UniProt: | Q4G0J3 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
