Description
Human LC3B/MAP1LC3B Recombinant Protein (N-His)
Human LC3B/MAP1LC3B Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Gly120, with an N-terminal His tag. Predicted molecular weight: 16.29 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Microtubule-associated protein 1 light chain 3 beta (LC3B/MAP1LC3B) is a ~14 kDa protein. Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). For research use only.
Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
| Product Name: | Human LC3B/MAP1LC3B Recombinant Protein (N-His) |
| SKU: | GXRP03500 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | MAP1A/MAP1B light chain 3 B, MAP1 light chain 3-like protein 2, MAP1ALC3, MAP1LC3B, Autophagy-related protein LC3 B, Microtubule-associated protein 1 light chain 3 beta, Microtubule-associated proteins 1A/1B light chain 3B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1A/MAP1B LC3 B |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Gly120 |
| Calculated MW: | 16.29 kDa |
| UniProt: | Q9GZQ8 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
