Description
Human LRP8 Recombinant Protein (N-His)
Human LRP8 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Pro447-Ile675, with an N-terminal His tag. Predicted molecular weight: 28.37 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Low-density lipoprotein receptor-related protein 8 (LRP8) is a ~105 kDa protein. Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. For research use only.
LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development.
| Product Name: | Human LRP8 Recombinant Protein (N-His) |
| SKU: | GXRP02249 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | LRP8, LRP-8, Low-density lipoprotein receptor-related protein 8, APOER2, Apolipoprotein E receptor 2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Pro447-Ile675 |
| Calculated MW: | 28.37 kDa |
| UniProt: | Q14114 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
