Description
Human Malin Recombinant Protein (N-His)
Human Malin Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Gly112-Gly395, with an N-terminal His tag. Predicted molecular weight: 32.57 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. E3 ubiquitin-protein ligase NHLRC1 is a ~42 kDa protein. E3 ubiquitin-protein ligase. For research use only.
Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation.
| Product Name: | Human Malin Recombinant Protein (N-His) |
| SKU: | GXRP10482 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | E3 ubiquitin-protein ligase NHLRC1, EC:2.3.2.27, EPM2B, Malin, NHL repeat-containing protein 1, NHLRC1, RING-type E3 ubiquitin transferase NHLRC1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Gly112-Gly395 |
| Calculated MW: | 32.57 kDa |
| UniProt: | Q6VVB1 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
