Description
Human MAP2K5 Recombinant Protein (N-His)
Human MAP2K5 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser144-Pro448, with an N-terminal His tag. Predicted molecular weight: 36.54 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Dual specificity mitogen-activated protein kinase kinase 5 is a ~50 kDa protein. Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. For research use only.
Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM.
| Product Name: | Human MAP2K5 Recombinant Protein (N-His) |
| SKU: | GXRP11471 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 5, EC:2.7.12.2, MAP kinase kinase 5, MAP2K5, MAPK/ERK kinase 5, MAPKK 5, MEK 5, MEK5, MKK5, PRKMK5 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser144-Pro448 |
| Calculated MW: | 36.54 kDa |
| UniProt: | Q13163 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
