Description
Human MARCHF1 Recombinant Protein (N-His)
Human MARCHF1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Lys154, with an N-terminal His tag. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. E3 ubiquitin-protein ligase MARCHF1 is a ~32 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. For research use only.
By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. Also regulates insulin sensitivity by controlling surface expression of the insulin receptor subunit beta/INSR by direct ubiquitination and degradation.
| Product Name: | Human MARCHF1 Recombinant Protein (N-His) |
| SKU: | GXRP13809 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | E3 ubiquitin-protein ligase MARCHF1, EC:2.3.2.27, MARCH-I, MARCH1, MARCHF1, Membrane-associated RING finger protein 1, Membrane-associated RING-CH protein I, RING finger protein 171, RING-type E3 ubiquitin transferase MARCHF1, RNF171 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Lys154 |
| UniProt: | Q8TCQ1 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
