Human MMP10 Recombinant Protein (RPPB1970)
- SKU:
- RPPB1970
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P09238
- Research Area:
- Enzymes
Description
| Product Name: | Human MMP10 Recombinant Protein |
| Product Code: | RPPB1970 |
| Size: | 25µg |
| Species: | Human |
| Target: | MMP10 |
| Synonyms: | SL-2, STMY2, Stromelysin-2, Matrix metalloproteinase-10, MMP-10, Transin-2, MMP10. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MMP10 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSFSSFPGM PKWRKTHLTY RIVNYTPDLP RDAVDSAIEK ALKVWEEVTP LTFSRLYEGE ADIMISFAVK EHGDFYSFDG PGHSLAHAYP PGPGLYGDIH FDDDEKWTED ASGTNLFLVA AHELGHSLGL FHSANTEALM YPLYNSFTEL AQFRLSQDDV NGIQSLYGPP PASTEEPLVP TKSVPSGSEM PAKCDPALSF DAISTLRGEY LFFKDRYFWR RSHWNPEPEF HLISAFWPSL PSYLDAAYEV NSRDTVFIFK GNEFWAIRGN EVQAGYPRGI HTLGFPPTIR KIDAAVSDKE KKKTYFFAAD KYWRFDENSQ SMEQGFPRLI ADDFPGVEPK VDAVLQAFGF FYFFSGSSQF EFDPNARMVT HILKSNSWLH C |
MMP10 (Matrix Metallopeptidase 10) which is a part of the matrix metalloproteinase (MMP) is activating procollagenase. MMP10 is part of a cluster of MMP genes which localize to chromosome 11q22.3. MMP10 takes part in the breakdown of extracellular matrix in normal physiological processes, like embryonic development, reproduction, and tissue remodeling, as also in disease processes, such as arthritis and metastasis. The majority MMP's are secreted as inactive proproteins that are activated when cleaved by extracellular proteinases. MMP10 encodes an enzyme which degrades proteoglycans and fibronectin.
MMP10 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 401 amino acids (99-476a.a) and having a molecular mass of 45.4kDa. MMP10 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MMP10: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase. Belongs to the peptidase M10A family. |
| UniProt Protein Details: | Protein type:EC 3.4.24.22; Secreted; Protease; Extracellular matrix; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q22.3 Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region Molecular Function:zinc ion binding; metalloendopeptidase activity; calcium ion binding Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis; regulation of cell migration |
| NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09238 |
| NCBI GenInfo Identifier: | 116869 |
| NCBI Gene ID: | 4319 |
| NCBI Accession: | P09238.1 |
| UniProt Secondary Accession: | P09238,Q53HH9, B2R9X9, |
| UniProt Related Accession: | P09238 |
| Molecular Weight: | 476 |
| NCBI Full Name: | Stromelysin-2 |
| NCBI Synonym Full Names: | matrix metallopeptidase 10 (stromelysin 2) |
| NCBI Official Symbol: | MMP10�� |
| NCBI Official Synonym Symbols: | SL-2; STMY2�� |
| NCBI Protein Information: | stromelysin-2; MMP-10; transin 2; transin-2; stromelysin 2; matrix metalloprotease 10; matrix metalloproteinase-10; matrix metalloproteinase 10 (stromelysin 2) |
| UniProt Protein Name: | Stromelysin-2 |
| UniProt Synonym Protein Names: | Matrix metalloproteinase-10; MMP-10; Transin-2 |
| Protein Family: | Stromelysin |
| UniProt Gene Name: | MMP10�� |
| UniProt Entry Name: | MMP10_HUMAN |
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