Description
Human MOB1A Recombinant Protein (N-His)
Human MOB1A Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Arg216, with an N-terminal His tag. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. MOB kinase activator 1A is a ~25 kDa protein. Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. For research use only.
The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.
| Product Name: | Human MOB1A Recombinant Protein (N-His) |
| SKU: | GXRP13634 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | C2orf6, MOB kinase activator 1A, MOB1A, MOB4B, MOBK1B, MOBKL1B, Mob1 alpha, Mob1 homolog 1B, Mob1A, Mps one binder kinase activator-like 1B |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Arg216 |
| UniProt: | Q9H8S9 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
