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Key Features

GenieFluor 488 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410] (AGEL0687)

Datasheet MSDS
SKU AGEL0687
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Human
Reactivity Mouse
Reactivity Rat
Host Species Mouse
Isotype IgG2a,k
Clone MIAP410
Conjugation AF 488
€113 - €275

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Description

system_update_altDatasheetsystem_update_altMSDS

GenieFluor 488 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]

The CD47 Monoclonal Antibody (AF488 Conjugated) (MIAP410) is a cutting-edge tool designed for the detection and analysis of CD47, a cell surface protein known for its role in immune response modulation. This monoclonal antibody, conjugated with AF488 for enhanced fluorescence detection, is compatible with human, mouse, and rat samples, offering versatility for a wide range of research applications.CD47, also referred to as integrin-associated protein, is a crucial molecule involved in "self" recognition and immune evasion mechanisms. Its functions include regulating phagocytosis, cell migration, and T-cell activation, making it a promising target for investigations in immunology and cancer biology. By specifically binding to CD47, the antibody facilitates the visualization and characterization of this protein in various cell types, aiding researchers in elucidating its involvement in diseases such as cancer, autoimmune disorders, and inflammatory conditions.

With its high reactivity and specificity, the CD47 Monoclonal Antibody (AF488 Conjugated) (MIAP410) is a valuable asset for studies aiming to unravel the complex interplay between the immune system and disease pathogenesis. Whether used in flow cytometry, immunofluorescence, or other experimental techniques, this antibody empowers researchers to delve deeper into the intricate mechanisms governed by CD47, paving the way for novel therapeutic strategies and potential clinical interventions.

Product Title:GenieFluor 488 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]
SKU:AGEL0687
Size:25µg, 100µg
Clone No:MIAP410
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human;Mouse;Rat
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor 488 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q08722 Q61735 P97829
Gene ID:961,16423,29364
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.
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