Description
Human MTF2 Recombinant Protein (N-His)
Human MTF2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Lys45-Lys335, with an N-terminal His tag. Predicted molecular weight: 35.79 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Metal-response element-binding transcription factor 2 is a ~67 kDa protein. Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. For research use only.
Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally.
| Product Name: | Human MTF2 Recombinant Protein (N-His) |
| SKU: | GXRP11942 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | MTF2, Metal regulatory transcription factor 2, Metal-response element DNA-binding protein M96, Metal-response element-binding transcription factor 2, PCL2, Polycomb-like protein 2, hPCl2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Lys45-Lys335 |
| Calculated MW: | 35.79 kDa |
| UniProt: | Q9Y483 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
