Human MUC2 Recombinant Protein (N-His) (GXRP03930)

Human MUC2 Recombinant Protein (N-His)

Human MUC2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ala4770-Ala5169, with an N-terminal His tag. Predicted molecular weight: 44.33 kDa. Purity: >90% as determined by SDS-PAGE. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Mucin-2 (MUC2) is a ~550 kDa protein. Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. For research use only.

Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine. MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange. Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells. Binds both Cu(2+) and its reduced form, Cu(1+), at two juxtaposed binding sites: Cu(2+), once reduced to Cu(1+) by vitamin C (ascorbate) or other dietary antioxidants, transits to the other binding site.