Description
Human NOTCH2NLA Recombinant Protein (N-His)
Human NOTCH2NLA Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Asn236, with an N-terminal His tag. Predicted molecular weight: 28 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) is a ~25 kDa protein. Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. For research use only.
Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2. Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation.
| Product Name: | Human NOTCH2NLA Recombinant Protein (N-His) |
| SKU: | GXRP02501 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Notch homolog 2 N-terminal-like protein A, NOTCH2NL, Notch homolog 2 N-terminal-like protein, N2N, NOTCH2NLA |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Asn236 |
| Calculated MW: | 28 kDa |
| UniProt: | Q7Z3S9 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
