Description
Human NOTCH4 Recombinant Protein (N-His)
Human NOTCH4 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Asp1715-Lys2002, with an N-terminal His tag. Predicted molecular weight: 31.93 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Neurogenic locus notch homolog protein 4 (NOTCH4) is a ~209 kDa protein. Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. For research use only.
Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.
| Product Name: | Human NOTCH4 Recombinant Protein (N-His) |
| SKU: | GXRP02748 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | NOTCH4, INT3, hNotch4, Neurogenic locus notch homolog protein 4, Notch 4 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Asp1715-Lys2002 |
| Calculated MW: | 31.93 kDa |
| UniProt: | Q99466 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
