Description
Human NPC1L1 Recombinant Protein (N-His)
Human NPC1L1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Arg450-Ser620, with an N-terminal His tag. Predicted molecular weight: 21.74 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. NPC1-like intracellular cholesterol transporter 1 (NPC1L1) is a ~148 kDa protein. Plays a major role in cholesterol homeostasis. For research use only.
Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia. May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation.
| Product Name: | Human NPC1L1 Recombinant Protein (N-His) |
| SKU: | GXRP04018 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | NPC1L1, Niemann-Pick C1-like protein 1, NPC1-like intracellular cholesterol transporter 1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Arg450-Ser620 |
| Calculated MW: | 21.74 kDa |
| UniProt: | Q9UHC9 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
