Description
Human NR1D2 Recombinant Protein (N-His)
Human NR1D2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Lys396-Pro579, with an N-terminal His tag. Predicted molecular weight: 23.07 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Nuclear receptor subfamily 1 group D member 2 (NR1D2) is a ~64 kDa protein. Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. For research use only.
Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element.
| Product Name: | Human NR1D2 Recombinant Protein (N-His) |
| SKU: | GXRP05711 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Rev-erb alpha-related receptor, V-erbA-related protein 1-related, Rev-erb-beta, NR1D2, Orphan nuclear hormone receptor BD73, RVR, Nuclear receptor subfamily 1 group D member 2, EAR-1R |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Lys396-Pro579 |
| Calculated MW: | 23.07 kDa |
| UniProt: | Q14995 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
