Description
Human NR1I2 Recombinant Protein (N-His)
Human NR1I2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser130-Ile431, with an N-terminal His tag. Predicted molecular weight: 36.84 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Nuclear receptor subfamily 1 group I member 2 (NR1I2) is a ~49 kDa protein. Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. For research use only.
Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites. Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. Target genes include cytochrome P450 enzymes such as CYP3A4 and ATP-binding cassette transporters including ABCB1/MDR1.
| Product Name: | Human NR1I2 Recombinant Protein (N-His) |
| SKU: | GXRP00240 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | NR1I2, SXR, PXR, Steroid and xenobiotic receptor, Orphan nuclear receptor PXR, Nuclear receptor subfamily 1 group I member 2, Pregnane X receptor, Orphan nuclear receptor PAR1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser130-Ile431 |
| Calculated MW: | 36.84 kDa |
| UniProt: | O75469 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
