Description
Human NR3C1 Recombinant Protein (N-His)
Human NR3C1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Val271-Lys777, with an N-terminal His tag. Predicted molecular weight: 59.09 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Glucocorticoid receptor (NR3C1) is a ~85 kDa protein. Receptor for glucocorticoids (GC). For research use only.
Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay.
| Product Name: | Human NR3C1 Recombinant Protein (N-His) |
| SKU: | GXRP00531 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | GR, NR3C1, Nuclear receptor subfamily 3 group C member 1, GRL, Glucocorticoid receptor |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Val271-Lys777 |
| Calculated MW: | 59.09 kDa |
| UniProt: | P04150 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
