Description
Human OTUB1 Recombinant Protein (N-His)
Human OTUB1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Lys271, with an N-terminal His tag. Predicted molecular weight: 33.45 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Ubiquitin thioesterase OTUB1 is a ~31 kDa protein. Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. For research use only.
Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy.
| Product Name: | Human OTUB1 Recombinant Protein (N-His) |
| SKU: | GXRP02710 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | OTU1, hOTU1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Deubiquitinating enzyme OTUB1, Otubain-1, OTUB1, Ubiquitin-specific-processing protease OTUB1, Ubiquitin thioesterase OTUB1, OTB1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Lys271 |
| Calculated MW: | 33.45 kDa |
| UniProt: | Q96FW1 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
