Description
Human OTUD4 Recombinant Protein (N-His)
Human OTUD4 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ala22-Val340, with an N-terminal His tag. Predicted molecular weight: 38.59 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. OTU domain-containing protein 4 (OTUD4) is a ~124 kDa protein. Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. For research use only.
May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions.
| Product Name: | Human OTUD4 Recombinant Protein (N-His) |
| SKU: | GXRP08363 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | OTU domain-containing protein 4, HIN-1, HIV-1-induced protein HIN-1, OTUD4, KIAA1046 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ala22-Val340 |
| Calculated MW: | 38.59 kDa |
| UniProt: | Q01804 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
