Description
Human PAK4 Recombinant Protein (N-His)
Human PAK4 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Val299-Ser542, with an N-terminal His tag. Predicted molecular weight: 29.88 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Serine/threonine-protein kinase PAK 4 (PAK4) is a ~64 kDa protein. Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival. For research use only.
Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin.
| Product Name: | Human PAK4 Recombinant Protein (N-His) |
| SKU: | GXRP00343 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | p21-activated kinase 4, Serine/threonine-protein kinase PAK 4, KIAA1142, PAK-4, PAK4 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Val299-Ser542 |
| Calculated MW: | 29.88 kDa |
| UniProt: | O96013 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
