Description
Human PBLD Recombinant Protein (N-His)
Human PBLD Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Ala288, with an N-terminal His tag. Predicted molecular weight: 33.95 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Phenazine biosynthesis-like domain-containing protein is a ~31 kDa protein. Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response. For research use only.
PBLD enhances IFN-I signaling via multiple pathways. Promotes IRF3-mediated IFN-I production and apoptosis, thereby inhibiting viral replication. Upregulates IFN-I response by activating the NF-kappaB signaling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection. Additionally, promotes the p53-USP4-MAVS signaling axis by stabilizing MAVS through USP4-mediated deubiquitination, thereby enhancing the IFN-I response against RNA virus infection.
| Product Name: | Human PBLD Recombinant Protein (N-His) |
| SKU: | GXRP09138 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Phenazine biosynthesis-like domain-containing protein; 5.1.-.-; MAWD-binding protein; MAWDBP; Unknown protein 32 from 2D-page of liver tissue; PBLD; MAWBP |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Ala288 |
| Calculated MW: | 33.95 kDa |
| UniProt: | P30039 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
