Description
Human PDE8A Recombinant Protein (N-His)
Human PDE8A Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser480-Glu829, with an N-terminal His tag. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is a ~93 kDa protein. Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. For research use only.
May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine.
| Product Name: | Human PDE8A Recombinant Protein (N-His) |
| SKU: | GXRP13070 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | EC:3.1.4.53, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, PDE8A |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser480-Glu829 |
| UniProt: | O60658 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
