Description
Human PIM3 Recombinant Protein (N-His)
Human PIM3 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Cys309, with an N-terminal His tag. Predicted molecular weight: 36.35 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Serine/threonine-protein kinase pim-3 (PIM3) is a ~35 kDa protein. Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. For research use only.
May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
| Product Name: | Human PIM3 Recombinant Protein (N-His) |
| SKU: | GXRP02522 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | PIM3, Serine/threonine-protein kinase pim-3 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Cys309 |
| Calculated MW: | 36.35 kDa |
| UniProt: | Q86V86 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
