Description
Human PLA2G2D Recombinant Protein (N-His)
Human PLA2G2D Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Gly21-Cys145, with an N-terminal His tag. Predicted molecular weight: 16.83 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Group IID secretory phospholipase A2 (PLA2G2D) is a ~16 kDa protein. Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions. For research use only.
Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins. During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response. May act in an autocrine and paracrine manner.
| Product Name: | Human PLA2G2D Recombinant Protein (N-His) |
| SKU: | GXRP03078 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | PLA2IID, SPLASH, Group IID secretory phospholipase A2, sPLA2-IID, Secretory-type PLA, stroma-associated homolog, GIID sPLA2, Phosphatidylcholine 2-acylhydrolase 2D, PLA2G2D |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Gly21-Cys145 |
| Calculated MW: | 16.83 kDa |
| UniProt: | Q9UNK4 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
