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Human PLSCR1 Recombinant Protein (RPPB4261)

SKU:
RPPB4261
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O15162
€273
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Description

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Product Name:Human PLSCR1 Recombinant Protein
Product Code:RPPB4261
Size:10µg
Species:Human
Target:PLSCR1
Synonyms:MMTRA1B, Phospholipid scramblase 1, PL scramblase 1, Ca(2+)-dependent phospholipid scramblase 1, Erythrocyte phospholipid scramblase,MmTRA1b.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:PLSCR1 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl,30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MDKQNSQMNA SHPETNLPVG YPPQYPPTAF QGPPGYSGYP GPQVSYPPPP AGHSGPGPAG FPVPNQPVYN QPVYNQPVGA AGVPWMPAPQ PPLNCPPGLE YLSQIDQILI HQQIELLEVL TGFETNNKYE IKNSFGQRVY FAAEDTDCCT RNCCGPSRPF TLRIIDNMGQ EVITLERPLR CSSCCCPCCL QEIEIQAPPG VPIGYVIQTW HPCLPKFTIQ NEKREDVLKI SGPCVVCSCC GDVDFEIKSL DEQCVVGKIS KHWTGILREA FTDADNFGIQ FPLDLDVK

Phospholipid scramblase (PLSCR1) is a member of the phospholipid scramblase family.�PLSCR1 has a significant part in the antiviral reaction of IFN by intensifying and improving the IFN reaction via increasing expression of select subset of potent antiviral genes. PLSCR1 promotes cytokine-regulated cell proliferation and differentiation.

PLSCR1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-288 a.a.) and having a molecular mass of 33.8kDa.PLSCR1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PLSCR1: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Belongs to the phospholipid scramblase family.
UniProt Protein Details:

Protein type:Calcium-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: extracellular matrix; Golgi apparatus; membrane; integral to plasma membrane; nucleolus; plasma membrane; cytosol; nucleus; lipid raft

Molecular Function:phospholipid scramblase activity; protein binding; enzyme binding; DNA binding; calcium ion binding; CD4 receptor binding; SH3 domain binding; epidermal growth factor receptor binding

Biological Process: platelet activation; negative regulation of viral genome replication; apoptosis; positive regulation of innate immune response; acute-phase response; positive regulation of transcription from RNA polymerase II promoter; phospholipid scrambling; defense response to virus; regulation of mast cell activation; phosphatidylserine biosynthetic process

UniProt Code:O15162
NCBI GenInfo Identifier:14548191
NCBI Gene ID:5359
NCBI Accession:O15162.1
UniProt Secondary Accession:O15162,B2R8H8, B4DTE8,
UniProt Related Accession:O15162
Molecular Weight:318
NCBI Full Name:Phospholipid scramblase 1
NCBI Synonym Full Names:phospholipid scramblase 1
NCBI Official Symbol:PLSCR1��
NCBI Official Synonym Symbols:MMTRA1B��
NCBI Protein Information:phospholipid scramblase 1; PL scramblase 1; erythrocyte phospholipid scramblase; ca(2+)-dependent phospholipid scramblase 1
UniProt Protein Name:Phospholipid scramblase 1
UniProt Synonym Protein Names:Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MmTRA1b
Protein Family:Phospholipid scramblase
UniProt Gene Name:PLSCR1��
UniProt Entry Name:PLS1_HUMAN

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