Description
Human POU3F2 Recombinant Protein (N-His-SUMO)
Human POU3F2 Recombinant Protein (N-His-SUMO) is a recombinant protein expressed in E. coli, spanning Thr266-Gln351, with an N-terminal His-SUMO tag. Predicted molecular weight: 21.93 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. POU domain, class 3, transcription factor 2 (POU3F2) is a ~46 kDa protein. Transcription factor that plays a key role in neuronal differentiation. For research use only.
Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes.
| Product Name: | Human POU3F2 Recombinant Protein (N-His-SUMO) |
| SKU: | GXRP04815 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Brain-specific homeobox/POU domain protein 2, POU domain, class 3, transcription factor 2, Brain-2, OTF7, Oct-7, Nervous system-specific octamer-binding transcription factor N-Oct-3, Brn-2, Octamer-binding protein 7, OCT7, Octamer-binding transcription factor 7, POU3F2, BRN2, OTF-7 |
| Tag: | N-His-SUMO |
| Expression Host: | E. coli |
| Protein Length: | Thr266-Gln351 |
| Calculated MW: | 21.93 kDa |
| UniProt: | P20265 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
